Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy.
نویسندگان
چکیده
A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 4 شماره
صفحات -
تاریخ انتشار 2012